Page Contents: Abstract | Summary Chart

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Benghezal, M., Cornillon, S., Gebbie, L., Alibaud, L., Bruckert, F., Letourneur, F., Cosson, P., (2003) ' Synergistic control of cellular adhesion by transmembrane 9 proteins. ' Mol Biol Cell 14 2890-9

 

Abstract:The transmembrane 9 (TM9) family of proteins contains numerous members in eukaryotes. Although their function remains essentially unknown in higher eukaryotes, the Dictyostelium discoideum Phg1a TM9 protein was recently reported to be essential for cellular adhesion and phagocytosis. Herein, the function of Phg1a and of a new divergent member of the TM9 family called Phg1b was further investigated in D. discoideum. The phenotypes of PHG1a, PHG1b, and PHG1a/PHG1b double knockout cells revealed that Phg1a and Phg1b proteins play a synergistic but not redundant role in cellular adhesion, phagocytosis, growth, and development. Complementation analysis supports a synergistic regulatory function rather than a receptor role for Phg1a and Phg1b proteins. Together, these results suggest that Phg1 proteins act as regulators of cellular adhesion, possibly by controlling the intracellular transport in the endocytic pathway and the composition of the cell surface.
Status:	Published	Type:	Journal article	Source:	PUBMED	PubMed ID:	12857872

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	Genes addressed in this paper
	phg1A	phg1B	phg1c
Topics in this paper
Adhesion	X	X
Protein Physical Properties	X	X	X
Protein Functional Domain	X	X
Non-mammalian Gene Related			X
Strains/Constructs	X	X
Function/Process	X	X
Development/Morphogenesis	X	X
Endocytosis	X	X
DNA/RNA Sequence Features	X	X	X
Growth	X	X
Mutants/Phenotypes	X	X
Antibodies		X